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Updated: Aug 5, 2026

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Come to the Light Side: In Vivo Monitoring of Pseudomonas aeruginosa Biofilm Infections in Chronic Wounds in a Diabetic Hairless Murine Model
Published on: October 10, 2017
[Non-healing foot wound]
Summary
A chronic foot wound in a Sri Lankan man, initially unresponsive to surgery, was eventually diagnosed as tuberculosis. Prompt tuberculostatic therapy was initiated after the development of miliary tuberculosis.
Area of Science:
- Medicine
- Infectious Diseases
- Dermatology
Background:
- Tuberculosis (TB) is a significant global health concern, primarily affecting the lungs but capable of manifesting in various extrapulmonary forms.
- Minor trauma can, in rare cases, trigger the reactivation of latent tuberculosis infections.
- Suppurative chronic wounds present diagnostic challenges, especially when initial treatments are ineffective.
Observation:
- A young male patient from Sri Lanka presented with a non-healing, suppurative chronic wound on his right foot following minor trauma.
- Multiple surgical interventions failed to achieve wound closure, highlighting the atypical nature of the lesion.
- The patient subsequently developed severe miliary tuberculosis, prompting a re-evaluation of the foot wound's etiology.
Findings:
- The chronic foot wound was ultimately diagnosed as a manifestation of tuberculosis, likely reactivated by the initial trauma.
- The development of miliary tuberculosis indicated disseminated disease, underscoring the severity of the underlying infection.
- Initiation of tuberculostatic therapy led to the management of both the disseminated disease and the chronic wound.
Implications:
- This case highlights the importance of considering tuberculosis in the differential diagnosis of chronic, non-healing wounds, particularly in endemic regions or in patients with risk factors.
- Trauma-induced reactivation of tuberculosis, though rare, can lead to severe disseminated disease and unusual presentations.
- Early and accurate diagnosis of extrapulmonary tuberculosis is crucial for effective treatment and improved patient outcomes, preventing complications like miliary spread.
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