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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

1.2K
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
322
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

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Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
244
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

2.8K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
2.8K
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

150
Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
150
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

2.7K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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Related Experiment Video

Updated: Apr 14, 2026

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
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Metrology for drug delivery.

Peter Lucas, Stephan Klein

    Biomedizinische Technik. Biomedical Engineering
    |April 17, 2015
    PubMed
    Summary

    Infusion technology risks, especially at low flow rates (<1 ml/h) and with multiple pumps, stem from inadequate drug administration. A European project addressed these metrology challenges for safer drug delivery.

    Area of Science:

    • Biomedical Engineering
    • Metrology
    • Drug Delivery Systems

    Background:

    • Underestimated risks in infusion technology are linked to inadequate drug administration.
    • Challenges are pronounced with very low flow rates (<1 ml/h) and multi-pump systems.
    • Lack of awareness, system understanding, and metrology infrastructure contribute to infusion risks.

    Purpose of the Study:

    • To address technical challenges in infusion technology, particularly for low-flow rates.
    • To improve the metrological infrastructure for accurate drug delivery.
    • To present the results of the European research project "Metrology for Drug Delivery".

    Main Methods:

    • The study discusses results from the "Metrology for Drug Delivery" European research project.

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    Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

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  • Focus on metrological challenges and solutions for low-flow rate infusion.
  • Analysis of drug delivery systems involving multiple pumps.

    • Main Results:

    • Identified underestimated risks associated with infusion technology, particularly at low flow rates.
    • Highlighted technical challenges in achieving accurate drug administration.
    • Demonstrated advancements in metrology for drug delivery systems.

    Conclusions:

    • Improved metrology is crucial for mitigating risks in infusion therapy.
    • Addressing technical challenges enhances the safety and efficacy of drug delivery.
    • The "Metrology for Drug Delivery" project provided key insights into safer infusion practices.