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Notes from the field: infant botulism caused by Clostridium baratii type F - Iowa, 2013
Insights
Infant botulism caused by type F toxin, a rare condition, was diagnosed in a 9-day-old newborn. Prompt treatment with Botulism Immune Globulin Intravenous (Human) was initiated.
Area of Science:
- Pediatrics
- Infectious Diseases
- Toxicology
Background:
- Infant botulism is a serious condition caused by toxins produced by Clostridium botulinum bacteria.
- While types A and B are most common, other types of botulinum toxin can also cause illness.
Observation:
- A 9-day-old male infant presented with constipation, poor feeding, and respiratory failure.
- The infant rapidly deteriorated, becoming unresponsive and requiring intubation.
Findings:
- Preliminary stool studies identified botulinum toxin type F.
- Clostridium baratii type F was isolated from the infant's stool culture, confirming the diagnosis.
Implications:
- This case highlights the potential for rare botulinum toxin types, such as type F, to cause infant botulism.
- Early diagnosis and administration of Botulism Immune Globulin Intravenous (Human) are crucial for managing infant botulism, even with less common toxin types.
Abstract:
In June 2013, a male newborn aged 9 days (delivered after a full-term pregnancy) was brought to a hospital emergency department with a 2-day history of constipation, fussiness, and poor feeding. The mother reported her son's symptoms as excessive crying, reluctance to suck, and difficulty in swallowing milk. Within hours of arrival, the infant became less responsive and "floppy," and was intubated for respiratory failure. Infant botulism was suspected and Botulism Immune Globulin Intravenous (Human) (BIG-IV), licensed for the treatment of infant botulism types A and B, was administered on hospital day 2. Results of preliminary stool studies were reported positive for botulinum toxin type F on hospital day 3. Clostridium baratii type F was subsequently isolated in stool culture.
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