Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

16.9K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
16.9K
Genomics02:02

Genomics

42.0K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
42.0K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

7.3K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.3K
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

22.2K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
22.2K
Genetic Screens02:46

Genetic Screens

5.9K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.9K
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

54.5K
Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
54.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cysteine Reactivity Profiling Identifies Host Regulators of <i>Mycobacterium tuberculosis</i> Replication in Human Macrophages.

ACS infectious diseases·2026
Same author

Genetic suppression features ABHD18 as a Barth syndrome therapeutic target.

Nature·2025
Same author

A drug screening platform for protein expression levels in neurological disorders.

BioTechniques·2025
Same author

<i>In vivo</i> validation of the palmitoylation cycle as a therapeutic target in <i>NRAS</i>-mutant cancer.

bioRxiv : the preprint server for biology·2025
Same author

Tracking and measuring local protein synthesis in vivo.

Development (Cambridge, England)·2024
Same author

Inflammation causes insulin resistance in mice via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels.

Nature communications·2024

Related Experiment Video

Updated: Apr 14, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

930

GeneDig: a web application for accessing genomic and bioinformatics knowledge.

Radu M Suciu1, Emir Aydin2, Brian E Chen3,4

  • 1Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Montreal General Hospital, 1650 Cedar Ave, L7-224, Montréal, H3G 1A4, , Québec, Canada. mihai.suciu@mail.mcgill.ca.

BMC Bioinformatics
|April 19, 2015
PubMed
Summary

GeneDig.org offers a user-friendly web application for accessing and analyzing genomic, transcriptomic, and proteomic data. This tool provides faster and more efficient navigation of complex biological information for general users.

More Related Videos

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

10.6K
Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

5.5K

Related Experiment Videos

Last Updated: Apr 14, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

930
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

10.6K
Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

5.5K

Area of Science:

  • Bioinformatics
  • Genomics
  • Proteomics
  • Transcriptomics

Background:

  • Increasingly large volumes of '-omics' data present accessibility challenges.
  • Existing bioinformatics tools are often specialized and lack user-friendliness.
  • There is a need for integrated platforms that prioritize user experience.

Purpose of the Study:

  • To develop a web-based application for simplified access to '-omics' data.
  • To enhance the usability of genomic information navigation.
  • To facilitate bioinformatics analyses for a broader range of users.

Main Methods:

  • Development of GeneDig.org, a web-based application.
  • Implementation of a dynamic navigator for simultaneous display of genomic, RNA, and protein information.
  • Focus on user-centered design for intuitive data access.

Main Results:

  • GeneDig.org provides easy and efficient access to genomic information for general users.
  • The application enables simultaneous co-navigation of diverse '-omics' data.
  • Demonstrated over five-fold improvement in access speed and efficiency compared to existing methods.

Conclusions:

  • GeneDig.org serves as a user-friendly platform for bioinformatics integration.
  • The tool aims to broaden access to genomic navigation for diverse audiences.
  • It supports everyday biology research by simplifying complex data analysis.