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Renal dysfunction in adults during measles
A Chassort1, J Coutherut2, A Moreau-Klein3
1Service de maladies infectieuses et tropicales, CHU de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France.
Medecine Et Maladies Infectieuses
|April 21, 2015
Summary
Measles can cause acute kidney injury in adults, a rare complication. This study found that serum creatinine should be checked in all adult measles patients to detect potential renal dysfunction.
Area of Science:
- Infectious Diseases
- Nephrology
- Epidemiology
Background:
- Measles outbreaks in adults present opportunities to study complications.
- Limited data exists on measles-related renal dysfunction in adults.
Purpose of the Study:
- To investigate the occurrence and characteristics of renal dysfunction in adult measles patients during a 2008 epidemic in France.
Main Methods:
- Retrospective study of hospitalized, biologically confirmed measles cases (January-December 2011).
- Renal function assessed using the Modification of Diet in Renal Disease (MDRD) equation.
Main Results:
- 38 adult patients were included; 17 (45%) had a glomerular filtration rate below 90 mL/min.
- One patient experienced acute renal failure (GFR 37 mL/min) with proteinuria (2.8 g/L), recovering within 2 days.
Conclusions:
- Acute renal failure is a potential complication of measles in adults.
- Systematic assessment of serum creatinine is recommended for adult measles patients.
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