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Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags
Published on: January 17, 2019
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New "pyrene box" cages for adaptive guest conformations.
Dan Dumitrescu1, Florina Dumitru1, Yves-Marie Legrand1
1Adaptive Supramolecular Nanosystems Group, Institut Européen des Membranes, ENSCM/UMII/UMR-CNRS 5635, Pl. Eugène Bataillon, CC 047, 34095 Montpellier Cedex 5, France.
Organic Letters
|April 21, 2015
Summary
Researchers controlled guest molecule compression and coiling within crystalline capsules. By altering host crystal dimensions using different cations, they precisely managed guest molecule behavior, demonstrating tunable supramolecular assembly.
Area of Science:
- Supramolecular Chemistry
- Crystal Engineering
- Materials Science
Background:
- Guanidinium 1,3,5,8 pyrene-tetrasulfonate (PTS(4-)) forms crystalline capsules capable of encapsulating guest molecules.
- The internal dimensions of these host capsules influence the behavior of encapsulated guests.
- Controlling guest molecule conformation and compression within host structures is a key challenge in supramolecular chemistry.
Purpose of the Study:
- To investigate the influence of host crystal dimensions on the compression extent and coiling shape of the 1,12-diammoniumdodecane guest molecule.
- To demonstrate the tunability of guest molecule behavior by modifying the host's internal space.
- To explore the use of different guanidinium-based cations to control host-guest interactions.
Main Methods:
- Synthesis of guanidinium 1,3,5,8 pyrene-tetrasulfonate (PTS(4-)) crystalline capsules.
- Incorporation of 1,12-diammoniumdodecane as a guest molecule within the PTS(4-) capsules.
- Systematic variation of the cation (guanidinium (G(+)), amino-guanidinium (AG(+)), and diaminoguanidinium (A2G(+))) to alter the host crystal dimensions.
- Structural analysis to determine the compression extent and coiling shape of the guest molecule.
Main Results:
- The dimensions of the internal space of the PTS(4-) crystalline capsules can be effectively controlled by using different cations (G(+), AG(+), A2G(+)).
- Changes in the host capsule dimensions directly correlate with the compression extent of the 1,12-diammoniumdodecane guest.
- The coiling shape of the 1,12-diammoniumdodecane guest molecule is significantly influenced by the host's internal space, allowing for shape control.
Conclusions:
- The study successfully demonstrates the ability to control the compression and coiling of 1,12-diammoniumdodecane guests within PTS(4-) crystalline capsules.
- Modulating the host crystal dimensions through the choice of guanidinium-based cations provides a versatile strategy for tuning guest molecule behavior.
- This work offers a new approach for designing and controlling supramolecular assemblies with tailored guest properties.
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