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Association between BDNF levels and suicidal behaviour: a systematic review protocol.

Rebecca Eisen1, Stefan Perera2,3, Monica Bawor4,5

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This review examines brain-derived neurotrophic factor (BDNF) and suicidal behavior. Understanding BDNF levels may help identify individuals at higher risk for suicide.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Public Health

Background:

  • Suicide is a global health crisis, with suicidal behavior a key predictor.
  • Biological markers, such as brain-derived neurotrophic factor (BDNF), are increasingly studied for suicide risk.
  • BDNF, crucial for nervous system function, is implicated in psychiatric disorders and suicide, though its precise role in suicidal behavior requires clarification.

Purpose of the Study:

  • To systematically review existing literature on the relationship between BDNF levels and suicidal behavior.
  • To synthesize current evidence on BDNF as a potential biomarker for suicide risk.

Main Methods:

  • A comprehensive literature search of major databases (PubMed/MEDLINE, EMBASE, PsycINFO, CINAHL) was conducted.
  • Two independent reviewers screened articles using predefined criteria, with discrepancies resolved by consensus or a third reviewer.
  • The primary outcome is the association between BDNF levels and suicidal behavior; a meta-analysis will be performed if data permit. Quality and bias will be assessed.

Main Results:

  • This section is to be filled upon study completion.

Conclusions:

  • Findings will aid in the identification and treatment of individuals at elevated risk of suicide.
  • This review aims to clarify the role of BDNF in suicidal behavior, potentially informing clinical practice.