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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Modulation of alternative splicing by anticancer drugs

Sayeed Ur Rehman1, Mohammed Amir Husain1, Tarique Sarwar1

  • 1Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, India.

Wiley Interdisciplinary Reviews. RNA
|April 28, 2015
PubMed
Summary

Alternative splicing generates diverse protein isoforms, impacting cancer cell growth and apoptosis. Anticancer drugs can manipulate splicing, offering potential for novel cancer therapies by promoting pro-apoptotic forms.

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