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Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination
Published on: February 9, 2021
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In-vivo Light dosimetry for pleural PDT
Andreea Dimofte1, Timothy C Zhu1, Jarod C Finlay1
1Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA.
Summary
Photodynamic therapy (PDT) treatment time for pleural non-small cell lung cancer correlates linearly with treatment volume and surface area. This study quantifies light dosimetry for improved clinical guidelines.
Area of Science:
- Oncology
- Medical Physics
- Photomedicine
Background:
- Photodynamic therapy (PDT) is a cancer treatment using light to activate drugs.
- Accurate light dosimetry is crucial for predicting PDT outcomes, especially in thoracic applications.
- Pleural PDT is used for non-small cell lung cancer with pleural effusion.
Purpose of the Study:
- To investigate the relationship between PDT treatment time, thoracic treatment volume, and surface area.
- To quantify mean light fluence rate and its accuracy during pleural PDT.
- To establish clinical guidelines for future pleural PDT treatments.
Main Methods:
- In-vivo light dosimetry was performed on patients undergoing Photofrin-mediated pleural PDT.
- Isotropic detectors monitored fluence rate and cumulative fluence at multiple sites.
- Correlations between treatment time, area, and volume were analyzed.
Main Results:
- A linear correlation was found between treatment time and treatment area (t = 4.80 A).
- A similar linear correlation was observed between treatment time and treatment volume (t = 2.33 V).
- Mean fluence rate ranged from 37.84 to 94.05 mW/cm², with ±10% accuracy.
Conclusions:
- Treatment time in pleural PDT is predictable based on treatment volume and surface area.
- These findings support the use of integrating sphere theory and tissue optical properties.
- The results provide a basis for clinical guidelines in pleural PDT.
