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Updated: Apr 14, 2026

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
Published on: January 24, 2025
Acid-responsive nanospheres from an asparagine-derived amphiphile
Adelphe M Mfuh1, Mathew P D Mahindaratne2, Audrey E Yñigez-Gutierrez1
1Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249-1644, USA.
Abstract:
We describe the synthesis and self-assembly of an asparagine-derived amphiphile. The self-assembled systems formulated with the inclusion of cholesterol (0-50 mol%) show encapsulation for a hydrophobic model drug and rapidly disintegrate in response to mild acidic conditions.
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