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Supermacroporous chemically cross-linked poly(aspartic acid) hydrogels.

Benjámin Gyarmati1, E Zsuzsanna Mészár1, Lóránd Kiss2

  • 1Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, Budafoki út 8., H-1111 Budapest, Hungary.

Acta Biomaterialia
|April 30, 2015
PubMed
Summary
This summary is machine-generated.

Chemically cross-linked poly(aspartic acid) (PASP) hydrogels with interconnected pores were created using cryogelation. These supermacroporous materials show promise for biomedical scaffolding applications.

Keywords:
HydrogelMacroporous morphologyPoly(aspartic acid)Responsive character

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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomedical Engineering

Background:

  • Poly(aspartic acid) (PASP) hydrogels are valuable for biomedical applications.
  • Creating hydrogels with controlled supermacroporous structures is challenging.

Purpose of the Study:

  • To develop supermacroporous poly(aspartic acid) (PASP) hydrogels using cryogelation.
  • To investigate the morphology, pore interconnectivity, and mechanical properties of these PASP hydrogels.
  • To evaluate the potential of these hydrogels as scaffolding materials in biomedical applications.

Main Methods:

  • Solid-liquid phase separation via cryogelation of polysuccinimide (PSI) in dimethyl sulfoxide.
  • Characterization of hydrogel morphology using scanning electron microscopy (SEM).
  • Assessment of pore interconnectivity through flow resistance measurements and compression tests.

Main Results:

  • Supermacroporous interconnected pore structures were successfully achieved in PASP hydrogels.
  • Dimethyl sulfoxide as a solvent allowed for higher preparation temperatures and avoided water's volume expansion upon freezing.
  • SEM confirmed the porous morphology, and low flow resistance indicated high pore interconnectivity.
  • Compression tests demonstrated excellent re-swelling and shape recovery properties.

Conclusions:

  • Cryogelation is an effective method for preparing supermacroporous PASP hydrogels with interconnected pores.
  • The use of dimethyl sulfoxide offers advantages over water for this cryogelation process.
  • These cytocompatible, morphologically controllable, and pH-responsive PASP hydrogels are promising for biomedical scaffolding.