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Antifungal activity of silver nanoparticles obtained by green synthesis

Eduardo José J Mallmann1, Francisco Afrânio Cunha1, Bruno N M F Castro2

  • 1Grupo de Química de Materiais Avançados, Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará, Fortaleza, CE, Brazil.

Revista Do Instituto De Medicina Tropical De Sao Paulo
|April 30, 2015
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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
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