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Theories of aging: an ever-evolving field
P V Sergiev1, O A Dontsova1, G V Berezkin2
1Belozersky Institute of Physico-Chemical Biology, Moscow State University, Leninskie Gory 1, bld. 40, 119992, Moscow, Russia ; Chemistry Department, Moscow State University, Leninskie Gory, 1, bld. 3, 119992, Moscow, Russia.
Acta Naturae
|May 1, 2015
Summary
Cellular senescence, a key aging process, is explored in this review. We summarize current aging theories and research approaches to understand this complex biological phenomenon.
Area of Science:
- Gerontology
- Cell Biology
- Molecular Biology
Background:
- Cellular senescence is a fundamental biological process studied for centuries.
- Aging remains a complex and largely understood phenomenon despite increased life expectancy.
- Understanding senescence is crucial for addressing age-related decline.
Purpose of the Study:
- To provide a comprehensive summary of current aging theories.
- To review diverse approaches used to investigate the aging process.
- To consolidate knowledge on cellular senescence and its implications.
Main Methods:
- Literature review of established and emerging theories of aging.
- Analysis of experimental and observational approaches in aging research.
- Synthesis of findings from cellular and molecular studies.
Main Results:
- Multiple theories explain aging, including genetic, cellular, and systemic factors.
- Research employs diverse methodologies, from molecular analysis to population studies.
- Senescence is recognized as a multifaceted process with significant biological impact.
Conclusions:
- Aging is a complex, multifactorial process with no single unifying theory.
- Continued research into senescence and aging mechanisms is vital.
- Understanding aging holds potential for interventions to improve healthspan.
Keywords:
accumulation of damageadvanced glycation end-productaginglife expectancyreactive oxygen speciestelomeraseMore Related Videos
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