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Related Concept Videos

Proteomics01:33

Proteomics

10.2K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Phosphorylation01:02

Phosphorylation

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The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
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Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

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Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
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Phosphoproteomic Strategy for Profiling Osmotic Stress Signaling in Arabidopsis
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Phosphoproteomic Strategy for Profiling Osmotic Stress Signaling in Arabidopsis

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Databases for plant phosphoproteomics.

Waltraud X Schulze1, Qiuming Yao, Dong Xu

  • 1Department of Plant Systems Biology, Universität Hohenheim, Stuttgart, 70593, Germany, wschulze@uni-hohenheim.de.

Methods in Molecular Biology (Clifton, N.J.)
|May 2, 2015
PubMed
Summary
This summary is machine-generated.

This study reviews plant phosphoproteomic databases, including PhosPhAt, P3DB, and Medicago PhosphoProtein Database. These resources aid research into phosphorylation, a key process in plant signaling and development.

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Area of Science:

  • Plant Biology
  • Molecular Biology
  • Bioinformatics

Background:

  • Phosphorylation is a crucial posttranslational modification regulating plant signal transduction.
  • Large-scale phosphoproteomic studies have increased our understanding of plant responses to stress and development.
  • Online databases are essential for organizing and accessing this growing body of data.

Purpose of the Study:

  • To provide an overview of key online resources for plant phosphoproteomic data.
  • To highlight the utility of PhosPhAt, P3DB, and Medicago PhosphoProtein Database for researchers.
  • To facilitate access to information on plant phosphoproteins.

Main Methods:

  • Literature review of existing plant phosphoproteomic databases.
  • Description of the features and scope of PhosPhAt, P3DB, and Medicago PhosphoProtein Database.
  • Categorization of databases based on model organisms and plant types.

Main Results:

  • PhosPhAt serves as a dedicated resource for Arabidopsis phosphoproteins.
  • P3DB expands coverage to include phosphoproteomic data from crop plants.
  • Medicago PhosphoProtein Database offers specific insights into Medicago trunculata.

Conclusions:

  • These curated databases are invaluable tools for plant scientists.
  • The presented resources support research in plant signaling, stress response, and development.
  • Centralized access to phosphoproteomic data accelerates discovery in plant biology.