Related Experiment Videos
[Experimental studies for urinary incontinence. Effect of beta 2-agonists on the vesicourethral function]
Nihon Hinyokika Gakkai Zasshi. the Japanese Journal of Urology
|November 1, 1989
Summary
Selective beta 2-adrenoceptor agonists, terbutaline and clenbuterol, relaxed bladder and urethral smooth muscle while contracting external urethral striated muscle. These findings suggest potential benefits for treating urinary incontinence.
Area of Science:
- Pharmacology
- Urology
Context:
- The study investigates the effects of beta 2-adrenoceptor agonists on urinary tract smooth muscle.
- Understanding these effects is crucial for developing treatments for urinary incontinence.
Purpose:
- To evaluate the in vitro and in vivo effects of terbutaline and clenbuterol on rabbit urinary tract smooth muscle.
- To determine the potential of beta 2-adrenoceptor agonists in managing urinary incontinence.
Summary:
- Terbutaline and clenbuterol, selective beta 2-adrenoceptor agonists, decreased contractile force in detrusor and proximal urethral smooth muscle.
- These agonists increased basal tension in the external urethral striated muscle.
- Oral administration of clenbuterol increased bladder capacity and urethral closure pressure in vivo.
Impact:
- The findings suggest that beta 2-adrenoceptor agonists may offer a therapeutic approach for patients suffering from urinary incontinence.
- This research could lead to novel pharmacological interventions for bladder dysfunction.