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Biofluid proteases profiling in diabetes mellitus.

Fábio Trindade1, Rita Ferreira1, Francisco Amado2

  • 1QOPNA, Mass Spectrometry Center, Department of Chemistry, University of Aveiro, Aveiro, Portugal.

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|May 3, 2015
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Summary

Proteases play a role in diabetes mellitus (DM) pathogenesis beyond protein breakdown. This review highlights proteases and their inhibitors in DM, emphasizing degradomics for future diagnostic tools.

Keywords:
BiofluidsDiabetes mellitusInhibitorsProteases

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Proteomics

Background:

  • Proteases are enzymes involved in protein and peptide breakdown.
  • Their role in diseases like diabetes mellitus (DM) is gaining attention.
  • Understanding proteolytic systems in DM is crucial for managing complications.

Purpose of the Study:

  • To review the role of proteases and their inhibitors in the pathogenesis of diabetes mellitus (DM).
  • To highlight the application of degradomics in studying proteolytic systems in DM.
  • To discuss the potential of biofluid proteases as diagnostic and prognostic markers.

Main Methods:

  • Literature review focusing on proteases, their inhibitors, and degradomics in the context of DM.
  • Analysis of existing studies linking protease activity to DM and its complications.
  • Discussion of traditional versus degradomics approaches for protease assessment.

Main Results:

  • While the human degradome comprises over 500 proteases, only a few have been linked to DM and its vascular complications.
  • Degradomics offers a comprehensive approach to study proteases, surpassing traditional methods.
  • Protease activity in biofluids is fundamental to understanding DM-related proteolytic systems.

Conclusions:

  • Proteases are implicated in the pathogenesis of diabetes mellitus (DM) beyond simple catabolism.
  • Degradomics provides a powerful framework for investigating protease roles in DM.
  • Future research should focus on developing high-throughput technologies for identifying diagnostic and prognostic protease biomarkers.