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Kidney transplantation in highly sensitized patients
Stanley C Jordan1, Jua Choi2, Ashley Vo2
1Comprehensive Transplant Center, Kidney Transplant Program and Transplant Immunotherapy Program, Cedars-Sinai Medical Center, Los Angeles, CA, USA sjordan@cshs.org Stan.Jordan@cshs.org.
British Medical Bulletin
|May 4, 2015
Summary
Desensitization therapies improve kidney transplant success in incompatible recipients. Research is advancing with new biologics to enhance B-cell and antibody modification for better outcomes.
Area of Science:
- Nephrology
- Transplantation Immunology
Background:
- Desensitization therapies are crucial for highly incompatible kidney transplant recipients.
- Advancements in antibody detection and ABMR assessment drive progress.
- There's a growing need for FDA-approved desensitization treatments.
Purpose of the Study:
- To review and synthesize data on evolving desensitization protocols.
- To summarize developments in novel biologics for transplantation.
Main Methods:
- Review of collective experience with IVIG, rituximab, and plasma exchange.
- Analysis of evolving protocols and novel biologic agents.
- Synthesis of data on B-cell, antibody, and complement modification.
Main Results:
- High-dose IVIG, rituximab, and plasma exchange are common desensitization protocols.
- Experiences with agents like bortezomib are still developing.
- Novel biologics show promise for improving desensitization and ABMR treatment.
Conclusions:
- Desensitization protocols are evolving with new therapeutic strategies.
- Novel biologics targeting B-cells, antibodies, and complement activation are key.
- Further research is needed to optimize desensitization and ABMR treatment.
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