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Updated: Apr 13, 2026
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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
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West Nile virus-associated acute flaccid paralysis
1Department of Medicine, George Washington University, Washington, DC, USA.
BMJ Case Reports
|May 4, 2015
Summary
West Nile virus can cause acute flaccid paralysis, presenting with symptoms like inguinal pain and rash. Prompt diagnosis and treatment with corticosteroids led to the patient's recovery.
Area of Science:
- Neurology
- Infectious Diseases
- Public Health
Background:
- West Nile virus (WNV) is a leading cause of arboviral encephalitis in North America.
- Neurological manifestations of WNV infection can include meningitis, encephalitis, and acute flaccid paralysis (AFP).
- AFP is a rare but serious complication, often mimicking other neurological disorders.
Observation:
- A 43-year-old woman presented with inguinal pain, maculopapular rash on palms and soles, and inguinal lymphadenopathy.
- She rapidly developed left lower extremity flaccid paralysis with diminished reflexes.
- Cerebrospinal fluid analysis confirmed West Nile virus immunoglobulin G and M antibodies.
Findings:
- The patient received intravenous methylprednisolone for suspected WNV-associated neurological complications.
- Within 7 days, she demonstrated recovery of reflexes and progressive improvement in lower extremity strength.
- Discharge occurred on day 9 with a prednisone taper and outpatient follow-up.
Implications:
- This case highlights the importance of considering WNV infection in patients presenting with AFP, even without a clear travel history.
- Early recognition and management of WNV neurological disease, including AFP, may improve patient outcomes.
- Public health awareness regarding WNV transmission and prevention remains crucial, especially in endemic areas.
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