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Related Experiment Video

Updated: Apr 13, 2026

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos

Published on: June 6, 2016

Genes and Conditions Controlling Mammalian Pre- and Post-implantation Embryo Development.

G Anifandis¹, C I Messini², K Dafopoulos²

¹Department of Obstetrics and Gynaecology ; Embryology Lab, University of Thessalia, School of Health Sciences, Faculty of Medicine, Larisa, Greece.

Current Genomics

|May 5, 2015

Summary

This summary is machine-generated.

Embryo development relies on precise gene expression and DNA methylation patterns post-fertilization. Understanding these factors is crucial for producing healthy blastocysts and improving in vitro fertilization outcomes.

Keywords:

Assisted reproduction DNA methylation Human embryology Imprinting errors

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Area of Science:

Reproductive Biology
Developmental Biology
Epigenetics

Background:

Embryo quality is critical for successful in vitro fertilization (IVF).
Post-fertilization events significantly influence blastocyst quality, alongside oocyte quality.
Key genes (OCT, SOX2, NANOG) and signaling pathways (TGF-β, BMP) are involved in embryo development.

Purpose of the Study:

To review the role of genes and epigenetic modifications in pre-implantation embryo development.
To emphasize factors influencing gene expression and DNA methylation patterns.
To discuss the impact of in vitro culture conditions on gene expression in pre-implantation embryos.

Main Methods:

Literature review focusing on gene expression, DNA methylation, and embryo development.
Analysis of experimental genetic studies and their findings.
Discussion of in vitro fertilization (IVF) culture systems and prolonged culture effects.

Main Results:

Specific gene expression profiles are linked to healthy blastocyst production.
DNA methylation patterns are essential for genome stability and physiological embryo development.
Deviations in gene expression or DNA methylation can lead to apoptosis or chromosomal abnormalities.

Conclusions:

Proper regulation of gene expression and DNA methylation is vital for successful pre-implantation development.
In vitro culture conditions may affect gene expression, impacting embryo quality.
Further research into these epigenetic mechanisms can enhance IVF success rates.