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Tumor-associated antigen specific CD8+ T cells in hepatocellular carcinoma - a promising target for immunotherapy
Nathalie Schmidt1, Tobias Flecken2, Robert Thimme1
1Department of Medicine II; University Hospital Freiburg ; Freiburg, Germany.
Abstract:
Immunotherapy is a promising treatment option for patients with hepatocellular carcinoma (HCC). Indeed, CD8+ T-cell responses against various tumor antigens occur in these patients. However, these antitumoral T cells show a severely impaired effector function. Several immunosuppressive mechanisms contribute to this T-cell failure, including regulatory T cells and inhibitory receptors.
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