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Updated: Apr 13, 2026

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
Published on: February 21, 2025
Using α radiation to boost cancer immunity?
Jean-Baptiste Gorin1, Yannick Guilloux1, Alfred Morgenstern2
1INSERM UMR 892 - CRCNA ; Nantes, France ; University of Nantes ; Nantes, France ; CNRS UMR 6299 ; Nantes, France.
Abstract:
Radioimmunotherapy aims to deliver radiation directly to cancer cells by means of a tumor specific vector coupled to a radionuclide. Alpha radionuclides are very potent agents to treat disseminated cancer and metastasis. We have demonstrated that α radiation can also induce immunogenic cell death, reinforcing interest in their clinical development.
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