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Updated: Apr 13, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Vitamin B6 improves the immunogenicity of cisplatin-induced cell death
Fernando Aranda1, Norma Bloy1, Lorenzo Galluzzi1
1Equipe 11 labelisée par la Ligue Nationale contre le cancer; Centre de Recherche des Cordeliers ; Paris, France ; Université Paris Descartes/Paris 5 ; Sorbonne Paris Cité , Paris, France ; INSERM U1138; Paris, France ; Gustave Roussy Comprehensive Cancer Center ; Villejuif, France.
Abstract:
We have recently demonstrated that pyridoxine, a precursor of vitamin B6, increases the immunogenicity of non-small cell lung carcinoma (NSCLC) cells succumbing to cisplatin (cis-diamminedichloroplatinum(II), CDDP). Accordingly, pyridoxine promoted the antineoplastic activity of CDDP in NSCLC-bearing mice only in the presence of an intact immune system. These findings may have implications for the development of novel strategies to circumvent CDDP resistance.

