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Related Concept Videos

Burn Injuries01:22

Burn Injuries

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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Related Articles

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Same author

Skin grafting in burns.

Wounds : a compendium of clinical research and practice·2015
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Skin substitutes in burn care.

Chester N Paul1

  • 1Saint Elizabeth's Regional Burn and Wound Care Center, Lincoln, NE;

Wounds : a Compendium of Clinical Research and Practice
|May 6, 2015
PubMed
Summary

This review explores burn grafting materials beyond skin. While synthetic options have advanced, autograft remains the gold standard for burn coverage.

Area of Science:

  • * Burn treatment and reconstructive surgery.
  • * Wound healing and tissue regeneration.

Background:

  • * Historical use of non-skin graft materials for burn coverage is examined.
  • * Evolution of burn wound management strategies.

Purpose of the Study:

  • * To review the history and application of graft materials other than skin for treating partial- and full-thickness burns.
  • * To assess the comparative efficacy of various burn grafting techniques.

Main Methods:

  • * Comprehensive literature search using Medline and Google databases.
  • * Keywords included: skin graft, skin substitute, allograft, homograft, xenograft, heterograft, autograft, burn grafting, and burn coverage.
  • * Articles were screened for relevance, and pertinent references were reviewed.

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Main Results:

  • * Technological advancements have introduced various synthetic materials for burn grafting.
  • * Autograft continues to be the benchmark against which other burn graft resources are evaluated.

Conclusions:

  • * Despite innovations in synthetic burn grafting materials, autograft remains the established standard.
  • * Further research may focus on optimizing synthetic alternatives to match autograft outcomes.