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miR-23a blockade enhances adoptive T cell transfer therapy by preserving immune-competence in the tumor

Regina Lin1, John H Sampson2, Qi-Jing Li1

  • 1Department of Immunology; Duke University Medical Center ; Durham, NC, USA.

Oncoimmunology
|May 8, 2015
PubMed

In adoptive T cell transfer therapy (ACT), the antitumor efficacy of cytotoxic CD8+ T lymphocytes (CTLs) has been limited by tumor-induced immunosuppression. We have demonstrated that miR-23a blockade in tumor-specific CTLs conferred resilience to TGFβ-mediated immunosuppression, resulting in superior tumor control. Our studies highlight miR-23a in tumor-specific CTLs as a clinically relevant target to enhance ACT.

Keywords:
TGFβcancer immunotherapycytotoxic CD8+ T lymphocytesimmune evasionmicroRNA

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