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Related Experiment Video

Updated: Apr 12, 2026

Transvaginal Mesh Insertion in the Ovine Model
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Mesh for prolapse surgery: Why the fuss?

Smita Rajshekhar1, Sambit Mukhopadhyay2, Uwe Klinge3

  • 1Obstetrics & Gynaecology, Norfolk & Norwich University hospital, Norwich, UK smita.rajshekhar@yahoo.co.uk.

Post Reproductive Health
|May 9, 2015
PubMed
Summary

Pelvic organ prolapse surgery using synthetic mesh shows short-term benefits but lacks long-term safety data. Further research and registries are needed to determine optimal mesh use and patient selection for prolapse repair.

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Articles linked to this work by shared authors, journal, and citation graph.

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Area of Science:

  • Urogynecology
  • Biomaterials Science
  • Surgical Innovation

Background:

  • Pelvic organ prolapse (POP) is a prevalent gynecological condition requiring surgical intervention.
  • Surgical repair techniques for POP are evolving, with synthetic and biological grafts introduced for enhanced support.
  • Concerns regarding complications and medico-legal issues associated with synthetic mesh use in POP surgery are rising.

Purpose of the Study:

  • To evaluate the current evidence on synthetic mesh use in pelvic organ prolapse repair.
  • To highlight the limitations of existing studies regarding mesh efficacy and safety.
  • To emphasize the need for improved quality control and further research in mesh-based POP surgery.

Main Methods:

  • Review of existing randomized controlled trials (RCTs) and clinical reports on mesh vs. non-mesh POP repair.
Keywords:
Biological graftMedicines and Healthcare products Regulatory AgencyPelvic organ prolapseU.S. Food and Drugs Administrationsynthetic Mesh

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  • Analysis of short- to medium-term outcomes reported in the literature.
  • Identification of data gaps concerning long-term safety and comparative effectiveness.

    • Main Results:

    • Current RCTs with limited follow-up suggest mesh repair may be beneficial in the short to medium term.
    • Evidence is insufficient to definitively prove the long-term safety of mesh for all patients.
    • Specific indications for which different mesh materials are superior to non-mesh repair remain undefined.

    Conclusions:

    • Long-term safety and efficacy of synthetic mesh in pelvic organ prolapse repair require further investigation.
    • The development of meshes with improved biocompatibility for vaginal surgery may enhance outcomes.
    • Implementation of national mesh registries is crucial for monitoring effectiveness and safety, guiding future clinical practice.