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Metoclopramide-induced parkinsonism.
K D Sethi1, B Patel, K J Meador
1Department of Neurology, Medical College of Georgia, Augusta 30912-2366.
Southern Medical Journal
|December 1, 1989
Summary
Metoclopramide hydrochloride (Reglan) can cause parkinsonism, a movement disorder. Dose reduction in patients with renal failure is recommended to prevent this side effect.
Area of Science:
- Neurology
- Pharmacology
Background:
- Metoclopramide hydrochloride (Reglan) is commonly prescribed for upper gastrointestinal issues.
- While generally safe, reports link it to movement disorders.
Observation:
- Six cases of metoclopramide-induced parkinsonism were observed over two years.
- Five of these patients had concurrent renal failure.
Findings:
- Parkinsonism symptoms improved after discontinuing metoclopramide.
- Metoclopramide-induced parkinsonism is not uncommon.
Implications:
- Renal failure increases the risk of metoclopramide-induced parkinsonism.
- Dose adjustment in renally impaired patients can mitigate this risk.