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Motilin stimulates pepsinogen secretion in Suncus murinus
Chayon Goswami1, Toru Tanaka2, Takamichi Jogahara3
1Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama, Japan.
Biochemical and Biophysical Research Communications
|May 11, 2015
Summary
Motilin stimulates pepsinogen secretion in suncus via a cholinergic pathway. Ghrelin did not affect secretion, indicating a specific role for motilin in this gastrointestinal function.
Area of Science:
- Gastroenterology
- Neuroendocrinology
- Physiology
Background:
- Motilin and ghrelin are key gastrointestinal hormones regulating fasting-state motility.
- Their precise roles in regulating pepsinogen secretion remain incompletely understood.
- Suncus (Suncus murinus) serves as a model due to its production of both hormones.
Purpose of the Study:
- To investigate the effects of motilin and ghrelin on pepsinogen secretion in anesthetized suncus.
- To elucidate the underlying pathways involved in motilin-stimulated pepsinogen secretion.
Main Methods:
- Utilized a gastric lumen-perfusion system in anesthetized suncus.
- Administered carbachol, motilin, and ghrelin intravenously.
- Investigated pathways using acetylcholine receptor antagonists (atropine) and vagotomy.
Main Results:
- Intravenous carbachol and motilin significantly stimulated pepsinogen secretion.
- Motilin's effect was dose-dependent; ghrelin had no significant effect.
- Atropine completely blocked both carbachol- and motilin-induced secretion.
- Motilin-induced secretion persisted in vagotomized suncus.
Conclusions:
- Motilin, but not ghrelin, stimulates pepsinogen secretion in suncus.
- This motilin-induced secretion is mediated through a cholinergic pathway.
- The findings highlight a novel role for motilin in regulating gastric secretion via the vagus nerve.
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