Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Orthogonal Trajectories01:26

Orthogonal Trajectories

71
Orthogonal trajectories describe the geometric relationship between two families of curves that intersect each other at right angles. One illustrative case involves a family of parabolas that open sideways along the x-axis. These curves share a common shape but differ by a scaling parameter, resulting in a set of curves that all pass through the origin and widen at different rates.Determining Orthogonal TrajectoriesTo identify the orthogonal trajectories for these parabolas, the first step...
71
Introduction to Developmental Psychology01:27

Introduction to Developmental Psychology

1.7K
Developmental psychology explores the changes and continuities in human abilities throughout life, encompassing physical, cognitive, linguistic, and social dimensions. Human development is not restricted to growth, but includes aspects of decline, particularly in physical abilities as individuals age. Developmental psychologists seek to understand how people change as they age and how their mental and social skills evolve.Developmental MilestonesA key concept in developmental psychology is...
1.7K
Three Developmental Domains01:29

Three Developmental Domains

1.2K
Human development is typically examined across three main domains: physical, cognitive, and socio-emotional. These domains represent the significant areas of change and continuity throughout the lifespan, from infancy to late adulthood.
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and weight,...
1.2K
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

1.2K
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
1.2K
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

7.7K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
7.7K
The Uncertainty Principle04:08

The Uncertainty Principle

33.1K
Werner Heisenberg considered the limits of how accurately one can measure properties of an electron or other microscopic particles. He determined that there is a fundamental limit to how accurately one can measure both a particle’s position and its momentum simultaneously. The more accurate the measurement of the momentum of a particle is known, the less accurate the position at that time is known and vice versa. This is what is now called the Heisenberg uncertainty principle. He...
33.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Self-regulated learning and academic success in health professions students: A systematic review.

Medical teacher·2026
Same author

Aging in autism: A systematic review of cognitive, neural, and physical health findings.

Neuroscience and biobehavioral reviews·2026
Same author

Limited Discrepancy Between Cognitive Ability and Daily Living Skills in Autism: A Longitudinal Study From Ages 2-25.

Autism research : official journal of the International Society for Autism Research·2026
Same author

Author Correction: Autism spectrum disorder.

Nature reviews. Disease primers·2026
Same author

Parent perspectives on guided self-care approaches to ensure timely access to therapy in infants with food allergy.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology·2026
Same author

Emotion Dysregulation Predicts Impairments in Peer Interaction and Adaptive Functioning in Autistic Kindergartners.

Autism research : official journal of the International Society for Autism Research·2026
Same journal

Posthumously Diagnosed Myhre Syndrome Presenting With Pleural Remodeling and Endometrial Cancer.

American journal of medical genetics. Part C, Seminars in medical genetics·2026
Same journal

The International Consortium for Arthrogryposis: A Collaborative Framework for Early Detection, Care, Research, and Education.

American journal of medical genetics. Part C, Seminars in medical genetics·2026
Same journal

Apical Ectodermal Ridge Disruption and Hypoplastic Digits in Amyoplasia.

American journal of medical genetics. Part C, Seminars in medical genetics·2026
Same journal

Caring for Pediatric Clients With Arthrogryposis Multiplex Congenita: The Development of an Occupational Therapy Continuing Education Course.

American journal of medical genetics. Part C, Seminars in medical genetics·2026
Same journal

The EXPLAIN Study: Exploring Arthrogryposis Multiplex Congenita in Adults in Norway - A Description of Demographic, Medical, and Neurological Findings.

American journal of medical genetics. Part C, Seminars in medical genetics·2026
Same journal

Review of the Molecular and Developmental Basis of Myhre Syndrome, Bench Research.

American journal of medical genetics. Part C, Seminars in medical genetics·2026
See all related articles

Related Experiment Video

Updated: Feb 12, 2026

Eye Tracking Young Children with Autism
09:03

Eye Tracking Young Children with Autism

Published on: March 27, 2012

46.6K

Developmental trajectories as autism phenotypes.

Catherine Lord, Somer Bishop, Deborah Anderson

    American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
    |May 12, 2015
    PubMed
    Summary
    This summary is machine-generated.

    This study tracked autism behaviors from childhood to adulthood, revealing developmental trajectories. These changing patterns offer better phenotypes for understanding Autism Spectrum Disorder (ASD) and related conditions.

    Keywords:
    autism spectrum disorderdevelopment and behavioral phenotype

    More Related Videos

    Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
    12:21

    Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

    Published on: September 12, 2011

    25.9K
    Studying Cell Rolling Trajectories on Asymmetric Receptor Patterns
    04:24

    Studying Cell Rolling Trajectories on Asymmetric Receptor Patterns

    Published on: February 13, 2011

    9.9K

    Related Experiment Videos

    Last Updated: Feb 12, 2026

    Eye Tracking Young Children with Autism
    09:03

    Eye Tracking Young Children with Autism

    Published on: March 27, 2012

    46.6K
    Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
    12:21

    Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

    Published on: September 12, 2011

    25.9K
    Studying Cell Rolling Trajectories on Asymmetric Receptor Patterns
    04:24

    Studying Cell Rolling Trajectories on Asymmetric Receptor Patterns

    Published on: February 13, 2011

    9.9K

    Area of Science:

    • Neuroscience
    • Developmental Psychology
    • Genetics

    Background:

    • Autism Spectrum Disorder (ASD) research often uses cross-sectional data, which may not capture developmental changes in behavior.
    • Behavioral phenotypes are crucial for linking genetic findings to ASD, but static measures limit understanding of developmental trajectories.

    Purpose of the Study:

    • To quantitatively describe developmental trajectories of autism-related behaviors and general functioning.
    • To provide longitudinal behavioral phenotypes for neurobiological studies of ASD and overlapping conditions.
    • To examine changes in social-communication deficits, social adaptive functioning, repetitive sensory motor (RSM) behaviors, and insistence on sameness (IS) behaviors.

    Main Methods:

    • Longitudinal study of 85 participants referred for autism at age 2, followed into young adulthood.
    • Quantitative analysis of parent-reported data on social-communication, adaptive functioning, RSM, and IS behaviors.
    • Examination of diverse outcomes, including intellectual disability, persistent ASD difficulties, and age-appropriate functioning.

    Main Results:

    • Identified distinct developmental trajectories for various autism-related behaviors and adaptive functioning.
    • Demonstrated significant heterogeneity in outcomes, with some individuals achieving age-appropriate functioning by adulthood.
    • Highlighted the importance of longitudinal data over single time-point measures for behavioral phenotyping.

    Conclusions:

    • Developmental trajectories of behavior provide more nuanced phenotypes for ASD research than static measures.
    • Understanding these trajectories is essential for neurobiological studies investigating ASD and related conditions.
    • The study identified diverse outcomes in ASD, underscoring the need for individualized approaches.