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Tinnitus and hyperacusis involve hyperactivity and enhanced connectivity in auditory-limbic-arousal-cerebellar
Yu-Chen Chen1, Xiaowei Li2, Lijie Liu2
1Jiangsu Key Laboratory of Molecular Imaging and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.
Elife
|May 13, 2015
Summary
This study identifies the brain network underlying tinnitus and hyperacusis. Salicylate drug induced these conditions, revealing amplified neural responses in auditory pathways and connected brain regions.
Area of Science:
- Neuroscience
- Auditory Neuroscience
- Clinical Neurology
Background:
- Tinnitus (ringing in the ears) and hyperacusis (sound sensitivity) are common, debilitating auditory disorders.
- The precise neural mechanisms and brain regions responsible for these conditions remain largely unknown.
Purpose of the Study:
- To identify the neural substrate and network in the brain responsible for tinnitus and hyperacusis.
- To investigate the effects of salicylate-induced hearing loss on auditory processing and brain activity.
Main Methods:
- Induction of tinnitus and hyperacusis using the ototoxic drug salicylate in a model.
- Utilized behavioral, electrophysiological, and functional magnetic resonance imaging (fMRI) techniques.
- Analyzed resting-state fMRI and functional connectivity to map brain network alterations.
Main Results:
- Salicylate reduced cochlear output but amplified sound-evoked responses in the amygdala, medial geniculate, and auditory cortex.
- Resting-state fMRI showed hyperactivity in an auditory network including the inferior colliculus, medial geniculate, and auditory cortex.
- Enhanced functional connectivity was observed within the auditory network and with the cerebellum, amygdala, reticular formation, and hippocampus.
Conclusions:
- A specific neural network involving auditory pathways and associated structures underlies tinnitus and hyperacusis.
- The findings propose a model for distress, arousal, and gating in these auditory disorders.
- Identified key brain regions and connections crucial for understanding and potentially treating tinnitus and hyperacusis.
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