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Reversible Conjunctival Pigmentation Associated With Prostaglandin Use.
Daniel Y Choi1, Robert T Chang, Krishnan Yegnashankaran
1*Department of Ophthalmology, Byers Eye Institute, Stanford University †Mid-Peninsula Ophthalmology Medical Group, Palo Alto, CA.
Journal of Glaucoma
|May 14, 2015
Summary
Prostaglandin analogs (PGAs) can cause reversible conjunctival hyperpigmentation in patients with ocular hypertension. Discontinuing PGAs led to significant improvement in this condition, highlighting its potential reversibility.
Area of Science:
- Ophthalmology
- Dermatology
Background:
- Ocular hypertension management often involves prostaglandin analogs (PGAs).
- Conjunctival hyperpigmentation is a potential side effect of certain medications.
Observation:
- A 54-year-old male with ocular hypertension developed bilateral limbal conjunctival hyperpigmentation after six years of PGA use.
- The hyperpigmentation progressively increased over time.
Findings:
- Discontinuation of travoprost (a PGA) and switching to brinzolamide resulted in significant improvement of conjunctival pigmentation within a year.
- This case represents the first documented instance of PGA-induced conjunctival pigmentation that reversed upon medication cessation.
Implications:
- Clinicians should consider PGA-induced conjunctival hyperpigmentation as a reversible condition.
- Awareness of this side effect is crucial when evaluating conjunctival melanocytic lesions in patients using PGAs.
- This finding may influence long-term treatment strategies for ocular hypertension.
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