Related Experiment Video
Updated: Apr 12, 2026
09:30
Assessment of Long-term Depression Induction in Adult Cerebellar Slices
Published on: October 16, 2019
7.5K
Synaptic Multivesicular Release in the Cerebellar Cortex: Its Mechanism and Role in Neural Encoding and Processing
Shin'Ichiro Satake1,2, Tsuyoshi Inoue3, Keiji Imoto4,5
1Department of Information Physiology, National Institute for Physiological Sciences (NIPS), 5-1 Higashiyama, Myodaiji-cho, Okazaki, 444-8787, Japan. ssatake@nips.ac.jp.
Cerebellum (London, England)
|May 15, 2015
Summary
Multivesicular release (MVR) at cerebellar synapses is controlled by the distance between voltage-gated calcium channels and calcium sensors. This release impacts postsynaptic neuron excitability and neural processing.
Area of Science:
- Neuroscience
- Cell Biology
- Synaptic Transmission
Background:
- The strength of postsynaptic responses is determined by the number of synaptic vesicles released.
- Mechanisms controlling vesicle release at single synapses remain unclear.
Purpose of the Study:
- Investigate the role of Cav2.1 calcium channels in multivesicular release (MVR).
- Determine how topographical distance influences MVR at cerebellar glutamatergic synapses.
Main Methods:
- Studied rat cerebellar glutamatergic synapses (granule cells to molecular layer interneurons).
- Examined the impact of Cav2.1 channel proximity to exocytotic calcium sensors on MVR.
Main Results:
- Cav2.1 channels induce MVR at these synapses.
- Topographical distance between Cav2.1 channels and Ca(2+) sensors critically determines MVR.
- MVR significantly affects postsynaptic neuron excitability in physiological firing patterns.
Conclusions:
- MVR, regulated by Cav2.1 channel positioning, adds complexity to neural encoding in the cerebellar cortex.
- Understanding MVR is crucial for comprehending cerebellar function and neural processing.
Related Concept Videos
01:28Integration of Synaptic Events
6.4K
Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
6.4K
01:09Synaptic Signaling
7.2K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
7.2K
01:12Synaptic Signaling
82.1K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
82.1K
01:26Chemical Synapses
10.3K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
10.3K
01:26Chemical Synapses
12.7K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
12.7K
02:47The Synapse
138.8K
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
138.8K