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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Histone Modification02:32

Histone Modification

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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Neural Regulation01:37

Neural Regulation

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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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Related Experiment Video

Updated: Apr 12, 2026

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1
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Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1

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Epigenetic changes in neurology: DNA methylation in multiple sclerosis.

M Iridoy Zulet1, L Pulido Fontes2, T Ayuso Blanco1

  • 1Servicio de Neurología, Complejo Hospitalario de Navarra, Pamplona, Navarra, España.

Neurologia (Barcelona, Spain)
|May 16, 2015
PubMed
Summary

Epigenetics, particularly DNA methylation, may link environmental factors and genetic predisposition in Multiple Sclerosis (MS) development. Understanding these epigenetic changes offers new diagnostic and therapeutic possibilities for MS.

Keywords:
D vitaminDNA methylationEpigeneticsEpigenéticaEpstein Barr virus.Esclerosis múltipleMetilación del ADNMultiple SclerosisSmokingTabacoVirus Epstein BarrVitamina D

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Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
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Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
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Area of Science:

  • Neuroimmunology
  • Epigenetics
  • Genetics

Background:

  • Multiple Sclerosis (MS) etiology remains unclear, with environmental factors interacting with genetic predisposition.
  • Epigenetics, the study of gene expression changes without DNA alteration, offers a potential mechanism.
  • DNA methylation is a key epigenetic mechanism implicated in disease development.

Purpose of the Study:

  • To review the impact of environmental risk factors on epigenetic mechanisms in MS.
  • To explore the role of these epigenetic changes in MS pathogenesis.

Main Methods:

  • Literature review focusing on environmental risk factors and epigenetic modifications in Multiple Sclerosis.
  • Analysis of the implications of epigenetic alterations in disease development.

Main Results:

  • Environmental risk factors may influence epigenetic mechanisms relevant to MS.
  • DNA methylation could be a crucial link between genetic susceptibility and environmental triggers in MS.

Conclusions:

  • Epigenetic modifications are implicated in the pathogenesis of Multiple Sclerosis.
  • Further research into epigenetic alterations may identify novel biomarkers and therapeutic targets for MS.