Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

6.3K
Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
6.3K
Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion03:48

Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion

32.2K
Although gaseous molecules travel at tremendous speeds (hundreds of meters per second), they collide with other gaseous molecules and travel in many different directions before reaching the desired target. At room temperature, a gaseous molecule will experience billions of collisions per second. The mean free path is the average distance a molecule travels between collisions. The mean free path increases with decreasing pressure; in general, the mean free path for a gaseous molecule will be...
32.2K
Diffusion on Chromatography Columns01:07

Diffusion on Chromatography Columns

1.6K
In column chromatography, when an analyte is introduced as a narrow band at the top of the column, the solutes begin to separate and broaden, developing a Gaussian profile. This broadening occurs due to various factors, such as longitudinal diffusion.
Longitudinal diffusion occurs when the solute molecules in the mobile phase diffuse from the more concentrated center of the chromatographic band to the more dilute regions on either side, both towards and against the flow direction. This...
1.6K
Diffusion01:12

Diffusion

232.0K
Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
232.0K
Diffusion01:21

Diffusion

7.4K
Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
7.4K
Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

2.8K
Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Learning thresholds lead to stable language coexistence.

Physical review. E·2025
Same author

Optimizing the charge transport in redox-active gels: a computational study.

Soft matter·2024
Same author

Nearest-neighbor directed random hyperbolic graphs.

Physical review. E·2023
Same author

Theoretical Study of Microgel Functional Groups' Mobility.

The journal of physical chemistry. B·2023
Same author

Modification of Nuclear Compartments and the 3D Genome in the Course of a Viral Infection.

Acta naturae·2021
Same author

The Role of Liquid-Liquid Phase Separation in the Compartmentalization of Cell Nucleus and Spatial Genome Organization.

Biochemistry. Biokhimiia·2020

Related Experiment Video

Updated: Apr 12, 2026

Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels
11:34

Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels

Published on: September 8, 2016

10.9K

Anomalous diffusion in fractal globules.

M V Tamm1,2, L I Nazarov1, A A Gavrilov1,3

  • 1Physics Department, Moscow State University, 119991 Moscow, Russia.

Physical Review Letters
|May 16, 2015
PubMed
Summary
This summary is machine-generated.

The fractal globule model explains chromatin packing. Simulations show this unique state is metastable, with subdiffusive monomer motion supporting its role in eukaryotic nuclei.

More Related Videos

Spot Variation Fluorescence Correlation Spectroscopy for Analysis of Molecular Diffusion at the Plasma Membrane of Living Cells
05:56

Spot Variation Fluorescence Correlation Spectroscopy for Analysis of Molecular Diffusion at the Plasma Membrane of Living Cells

Published on: November 12, 2020

3.4K
Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
06:55

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

8.6K

Related Experiment Videos

Last Updated: Apr 12, 2026

Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels
11:34

Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels

Published on: September 8, 2016

10.9K
Spot Variation Fluorescence Correlation Spectroscopy for Analysis of Molecular Diffusion at the Plasma Membrane of Living Cells
05:56

Spot Variation Fluorescence Correlation Spectroscopy for Analysis of Molecular Diffusion at the Plasma Membrane of Living Cells

Published on: November 12, 2020

3.4K
Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
06:55

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

8.6K

Area of Science:

  • Biophysics
  • Computational Biology
  • Genomics

Background:

  • The fractal globule model is widely used to describe chromatin organization within eukaryotic nuclei.
  • Understanding chromatin dynamics is crucial for comprehending nuclear processes.

Purpose of the Study:

  • To investigate the thermal motion of monomers within the fractal globule state.
  • To provide a theoretical and computational framework for chromatin dynamics in this model.

Main Methods:

  • Development of a scaling theory for fractal globule dynamics.
  • Dissipative particle dynamics (DPD) computer simulations were employed.
  • Analysis of monomer motion and convergence from various initial states.

Main Results:

  • Simulations demonstrated convergence, supporting the existence of a unique, metastable fractal globule state.
  • Monomer motion was found to be subdiffusive, characterized by ⟨X(2)(t)⟩∼t(αF) with αF ≈ 0.4.
  • The simulated dynamics align well with experimental data on chromatin motion.

Conclusions:

  • The findings provide strong evidence for the fractal globule model as a valid description of chromatin packing.
  • The study validates the metastable nature of the fractal globule state.
  • Subdiffusive monomer motion is a key characteristic supporting the fractal globule model in eukaryotic nuclei.