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Update in primary pulmonary lymphomas
Jose Cardenas-Garcia1, Arunabh Talwar, Rakesh Shah
1aDivision of Pulmonary, Critical Care and Sleep Medicine bDepartment of Radiology, North Shore University Hospital, Hofstra North Shore-LIJ School of Medicine, Hempstead, New York, USA.
Current Opinion in Pulmonary Medicine
|May 16, 2015
Summary
Primary pulmonary lymphoma (PPL) diagnosis and treatment have advanced. Recent findings improve understanding of mucosa-associated lymphoid tissue (MALT) PPL, guiding clinical practice and future research for this rare lung tumor.
Area of Science:
- Pulmonology
- Oncology
- Pathology
Background:
- Primary pulmonary lymphoma (PPL) is a rare lung malignancy.
- Advances in understanding PPL have been made over the last decade.
Purpose of the Study:
- To review recent clinical features, diagnosis, prognosis, and treatment of PPL.
- To outline implications of new findings for PPL clinical practice and research.
Main Methods:
- Review of recent publications on PPL.
- Analysis of diagnostic techniques including fluorescence in-situ hybridization and biopsy methods.
- Evaluation of therapeutic approaches and prognostic factors.
Main Results:
- Monoclonality and phenotyping suggest mucosa-associated lymphoid tissue (MALT) in PPL.
- MALT-1 gene rearrangements confirm MALT PPL; various biopsies yield diagnostic tissue.
- Newer chemotherapies (fludarabine, mitoxantrone, rituximab) and surgery are treatment options; tumor microvascular density is a promising prognostic factor.
Conclusions:
- Recent findings offer insights into PPL management.
- Larger, multicenter studies are needed to optimize diagnostic and therapeutic strategies for PPL.
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