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Updated: Apr 12, 2026

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
Experimental efficacy of anidulafungin against Aspergillus terreus species complex
Marta Sanchis1, Javier Capilla1, Emilio Mayayo2
1Unitat de Microbiologia.
Abstract:
Whereas echinocandins are alternatives for the treatment of invasive aspergillosis, the efficacy of anidulafungin (AFG) against Aspergillus terreus infection has not yet been explored. We have evaluated the in vitro activity, as well as the in vivo efficacy of AFG in neutropenic mice infected by A. terreus species complex. Time-kill studies showed in vitro fungistatic activity of AFG against two strains. AFG at doses of 5 and 10 mg/kg/day significantly reduced the fungal load in kidney of mice, but only the higher dose was able to prolong survival.
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