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Updated: Apr 12, 2026
Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury
Published on: December 17, 2014
Pilot study: bone marrow stem cells as a treatment for dogs with chronic spinal cord injury
Carlos Alberto Palmeira Sarmento1, Marcio Nogueira Rodrigues2, Renato Zonzini Bocabello1
1School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, Brazil.
Background:
Chronic Spinal Cord injury is a common, severe, and medically untreatable disease. Since the functional outcomes of acute and experimental chronic spinal cord injury have been shown to improve with stem cell therapy, a case study was conducted to test if the application of stem cell also regenerates chronic SCI dysfunction. Transplantation of foetal bone marrow stem cells was applied in seven dogs with chronic spinal cord injury. Magnetic resonance images and assessments of symptoms according to the Olby scale were used to diagnose the severity of injury.
Result:
All dogs improved locomotor and sensory function when examined 90 days after surgery, and showed increased movement of the hind limbs, and were able to stand upright, as well as to take small steps. Tail tone was observed in seven dogs, pain reflexes and defecation return were observed in five dogs.
Conclusion:
The transplantation of bone marrow stem may be a promising, reliable and safe treatment for chronic spinal cord injury.
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