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Related Experiment Video

Updated: Apr 12, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

21.3K

Gold nanoparticles enhancing protontherapy efficiency.

Lorenzo Torrisi1

  • 1Dipartimento di Fisica & SdT, V.le F.S. D'Alcontres 31, 98166 S. Agata, Messina, Italy. Lorenzo.Torrisi@unime.it.

Recent Patents on Nanotechnology
|May 20, 2015
PubMed
Summary

Gold nanoparticles enhance radiation dose delivery in cancer radiotherapy. Injecting these nanoparticles into tumors increases absorbed radiation dose, potentially reducing patient exposure or boosting tumor targeting.

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Area of Science:

  • Medical Physics
  • Nanotechnology
  • Radiotherapy

Background:

  • Gold nanoparticles (AuNPs) can increase the effective atomic number of biological tissues.
  • This property is being explored to enhance radiation dose deposition in targeted areas.

Purpose of the Study:

  • To investigate the potential of gold nanoparticles for enhancing absorbed radiation dose in cancer radiotherapy.
  • To evaluate the Bragg peak enhancement in proton beam therapy using AuNPs.

Main Methods:

  • Utilizing simulation programs, specifically SRIM Code, to model proton energy loss in tissues.
  • Assessing the impact of varying concentrations of injectable AuNPs on absorbed dose.

Main Results:

  • Gold nanoparticles increase the absorbed radiation dose by approximately six percent at low concentrations.

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Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods
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  • Simulations demonstrate a significant enhancement of the Bragg peak in the presence of AuNPs.

    • Conclusions:

    • Injectable gold nanoparticles offer a promising method to improve radiotherapy efficacy.
    • AuNPs can either reduce radiation exposure or increase the dose delivered to tumor sites.