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Related Experiment Video

Updated: Apr 12, 2026

Corneal Donor Tissue Preparation for Descemet's Membrane Endothelial Keratoplasty
10:46

Corneal Donor Tissue Preparation for Descemet's Membrane Endothelial Keratoplasty

Published on: September 17, 2014

15.8K

Descemet membrane endothelial keratoplasty.

Marcus Ang1, Mark R Wilkins2, Jodhbir S Mehta3

  • 1Singapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore Moorfields Eye Hospital, London, UK.

The British Journal of Ophthalmology
|May 21, 2015
PubMed
Summary

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Descemet membrane endothelial keratoplasty (DMEK) offers selective endothelial cell replacement but faces limited adoption due to surgical challenges. Further research is needed to validate its benefits across diverse surgical centers.

Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Transplantation Science

Background:

  • Descemet membrane endothelial keratoplasty (DMEK) selectively replaces damaged corneal endothelial cells using donor tissue.
  • Limited adoption by corneal surgeons stems from challenges in donor preparation and surgical technique.
  • Graft detachment remains the most common postoperative complication following DMEK.

Purpose of the Study:

  • To review current literature on Descemet membrane endothelial keratoplasty (DMEK).
  • To identify challenges limiting DMEK adoption and areas for future research.
  • To assess the replicability of DMEK's purported advantages in broader clinical settings.

Main Methods:

  • Review of current literature on Descemet membrane endothelial keratoplasty (DMEK).
Keywords:
Cornea

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Corneal Donor Tissue Preparation for Endothelial Keratoplasty
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  • Analysis of graft registry data to illustrate adoption rates.
  • Identification of common postoperative complications and surgical challenges.

    • Main Results:

    • Early adoption rates for DMEK were low (0.7% in USA, 0.4% in Australia in 2011).
    • Innovative donor preparation and surgical techniques are improving outcomes and reducing graft detachment.
    • Most current publications originate from surgeons advocating the technique.

    Conclusions:

    • Further randomized controlled trials are necessary to compare clinical practices and surgeon preferences in DMEK.
    • Long-term clinical studies in multiple tertiary centers are required to confirm the replicability of DMEK's advantages, such as improved visual outcomes and reduced graft rejection.
    • Addressing surgical challenges and standardizing techniques are crucial for wider DMEK implementation.