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Updated: Apr 12, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Crystal structure of 3-bromo-methyl-2-chloro-6-(di-bromo-meth-yl)quinoline
Kasirajan Gayathri1, Palathurai S Mohan1, Judith A K Howard2
1Department of Chemistry, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.
Abstract:
In the title compound, C11H7Br3ClN, the quinoline ring system is approximately planar (r.m.s. = 0.011 Å). In the crystal, mol-ecules are linked by C-H⋯Br inter-actions forming chains along [10-1]. The chains are linked by C-H⋯π and π-π inter-actions involving inversion-related pyridine rings [inter-centroid distance = 3.608 (4) Å], forming sheets parallel to (10-1). Within the sheets, there are two significant short inter-actions involving a Br⋯Cl contact of 3.4904 (18) Å and a Br⋯N contact of 3.187 (6) Å, both of which are significantly shorter than the sum of their van der Waals radii.
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