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Historical evolution of the frontal lobe syndrome
Welmoed A Krudop1, Yolande A L Pijnenburg
1Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Abstract:
The function of the frontal lobes and the related frontal lobe syndrome have not been described in detail until relatively late in history. Slowly, the combination of knowledge from animal models, the detailed examination of symptoms after traumatic frontal lobe injuries, and the rise and fall of psychosurgery has led to increasing insight into frontal lobe function. The frontosubcortical circuits have been described and increasingly related to clinical syndromes, confirmed by the latest developments in functional connectivity networks.
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