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Microarray Analysis for Saccharomyces cerevisiae
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Biocuration at the Saccharomyces genome database.

Marek S Skrzypek1, Robert S Nash1

  • 1Department of Genetics, Saccharomyces Genome Database, Stanford University, Stanford, California.

Genesis (New York, N.Y. : 2000)
|May 23, 2015
PubMed
Summary

The Saccharomyces Genome Database uses expert biocurators to organize yeast research data. This manual curation adds biological context, transforming vast data into interconnected knowledge for researchers.

Area of Science:

  • * Genomics and Molecular Biology
  • * Bioinformatics and Computational Biology

Background:

  • * The Saccharomyces Genome Database (SGD) is a critical online resource for yeast (Saccharomyces cerevisiae) biology and genetics.
  • * Information in SGD is primarily sourced from scientific literature and meticulously curated by humans.

Purpose of the Study:

  • * To highlight the indispensable role of biocuration and biocurators in adding biological context to complex datasets.
  • * To explain how curated information facilitates the understanding of gene, protein, genome, and cellular functions and interactions.
  • * To demonstrate the value of manual curation in synthesizing extensive biological data into organized, interconnected knowledge.

Main Methods:

  • * Manual extraction and organization of data from scientific publications.
Keywords:
biocurationdatabaseyeast

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  • * Integration of information into a comprehensive knowledge system.
  • * Analysis of how biocurators add biological context to facilitate research.

    • Main Results:

    • * Biocuration provides essential biological context, enhancing the understanding of cellular mechanisms.
    • * SGD serves as a foundational resource for analyzing experimental data in yeast and other organisms.
    • * Manual curation transforms raw data into structured, interconnected knowledge vital for scientific advancement.

    Conclusions:

    • * Biocurators play an essential role in integrating scientific information into a coherent model of the cell.
    • * Manual curation is vital for converting large volumes of data into accessible and usable knowledge.
    • * The SGD resource, powered by biocuration, significantly aids researchers in diverse biological investigations.