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Related Concept Videos

Obesity01:24

Obesity

1.6K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.5K
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

404
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
404
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

303
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
303
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

346
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
346
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Updated: Apr 12, 2026

A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta
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A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta

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Pregnancy risks associated with obesity.

John F Mission1, Nicole E Marshall2, Aaron B Caughey2

  • 1Maternal-Fetal Medicine, Department of Obstetrics, Gynecology & Reproductive Sciences, Magee-Womens Hospital of UPMC, 300 Halket Street, Pittsburgh, PA 15213, USA.

Obstetrics and Gynecology Clinics of North America
|May 24, 2015
PubMed
Summary
This summary is machine-generated.

Obesity affects 40% of pregnant women, increasing risks for preeclampsia, gestational diabetes, and cesarean delivery. Higher body mass index correlates with worse maternal and fetal outcomes.

Keywords:
Gestational diabetesMacrosomiaObesityPregnancyPrenatal care

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Area of Science:

  • Obstetrics and Gynecology
  • Public Health
  • Reproductive Medicine

Background:

  • Obesity prevalence has significantly risen in the United States.
  • Approximately 40% of pregnant women are classified as overweight or obese.
  • Obesity is linked to a spectrum of adverse pregnancy complications.

Purpose of the Study:

  • To review the association between obesity and maternal, fetal, and pregnancy outcomes.
  • To discuss current recommendations for managing pregnant individuals with obesity.

Main Methods:

  • This is a review article.
  • It synthesizes existing literature on obesity in pregnancy.
  • It discusses established clinical recommendations.

Main Results:

  • Obesity is associated with increased rates of preeclampsia, gestational diabetes, and fetal macrosomia.
  • Stillbirth, postterm pregnancy, and cesarean delivery rates are elevated in obese pregnancies.
  • Complication severity often escalates with increasing body mass index in a dose-response manner.

Conclusions:

  • Obesity presents significant risks to both maternal and fetal well-being during pregnancy.
  • Evidence supports a dose-response relationship between body mass index and adverse outcomes.
  • Guidelines for the care of obese pregnant individuals are crucial for mitigating risks.