Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

1.5K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.5K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

754
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
754
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

1.1K
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
1.1K
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

1.5K
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
1.5K
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

840
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
840
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

3.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nano-Mod-Amp reveals RNA sequence, structural and cell type specific features of pseudouridylation by PUS7.

bioRxiv : the preprint server for biology·2025
Same author

CAR-SPLASH identifies nascent pre-mRNA structures implicated in kinetic coupling and alternative splicing.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Calcium handling abnormalities increase arrhythmia susceptibility in DMSXL myotonic dystrophy type 1 mice.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2024
Same author

Elevated Interleukin-6 Levels Are Associated With an Increased Risk of QTc Interval Prolongation in a Large Cohort of US Veterans.

Journal of the American Heart Association·2024
Same author

Electrophysiological basis of cardiac arrhythmia in a mouse model of myotonic dystrophy type 1.

Frontiers in physiology·2023
Same author

Pre-mRNA splicing and its cotranscriptional connections.

Trends in genetics : TIG·2023
Same journal

Sweating the Details: A Reflective Pause in our Procedural Workflow.

Cardiac electrophysiology clinics·2026
Same journal

Patent Foramen Ovale and Atrial Septal Defect.

Cardiac electrophysiology clinics·2026
Same journal

Patent Foramen Ovale Embryology, Anatomy, and Physiology.

Cardiac electrophysiology clinics·2026
Same journal

Management of Arrhythmias in the Cardiovascular Intensive Care Unit.

Cardiac electrophysiology clinics·2026
Same journal

Left Ventricular Assist Device Emergencies: Diagnosis and Management.

Cardiac electrophysiology clinics·2026
Same journal

Advanced Critical Care Techniques in the Field.

Cardiac electrophysiology clinics·2026
See all related articles

Related Experiment Video

Updated: Apr 12, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.8K

Left ventricular hypertrophy and arrhythmogenesis.

Mohammad Shenasa1, Hossein Shenasa1, Nabil El-Sherif2

  • 1Department of Cardiovascular Services, O'Connor Hospital, San Jose, CA 95128, USA; Heart and Rhythm Medical Group, 105 North Bascom Avenue, San Jose, CA 92128, USA.

Cardiac Electrophysiology Clinics
|May 24, 2015
PubMed
Summary
This summary is machine-generated.

Left ventricular hypertrophy (LVH) increases risks for heart arrhythmias and sudden death. Managing the underlying cause of LVH is key to improving heart function and reducing complications.

Keywords:
ArrhythmogenesisAtrial fibrillationHypertensionHypertensive heart diseaseLeft ventricular hypertrophyTorsades de pointesVentricular arrhythmias

More Related Videos

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure
09:37

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Published on: December 2, 2014

29.0K
Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding
10:39

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding

Published on: August 30, 2024

1.6K

Related Experiment Videos

Last Updated: Apr 12, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.8K
Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure
09:37

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Published on: December 2, 2014

29.0K
Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding
10:39

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding

Published on: August 30, 2024

1.6K

Area of Science:

  • Cardiology
  • Cardiovascular Medicine
  • Medical Diagnostics

Background:

  • Left ventricular hypertrophy (LVH) is a significant independent risk factor for cardiovascular morbidity and mortality.
  • LVH is associated with serious complications such as atrial and ventricular arrhythmias, and sudden cardiac death.
  • Hypertension and valvular heart disease are the primary etiological factors contributing to LVH.

Purpose of the Study:

  • To outline the diagnostic approaches for LVH.
  • To emphasize the importance of etiology-based management for LVH.
  • To highlight the benefits of timely and optimal intervention in LVH regression and complication reduction.

Main Methods:

  • Initial diagnosis and therapy evaluation commonly utilize electrocardiography and echocardiography.
  • Cardiac Magnetic Resonance (CMR) imaging is considered the gold standard for LVH diagnosis and assessing therapeutic response.
  • Management strategies are guided by the underlying etiology, current evidence, and established clinical guidelines.

Main Results:

  • Early detection and appropriate management of LVH are crucial for patient outcomes.
  • Addressing the root causes of LVH leads to regression of the condition.
  • Effective management reduces the incidence of associated arrhythmias and sudden cardiac death.

Conclusions:

  • LVH necessitates prompt and accurate diagnosis and management.
  • Personalized treatment strategies based on etiology and evidence improve LVH regression.
  • Optimal management of LVH significantly mitigates associated cardiovascular risks, enhancing patient survival and quality of life.