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Updated: Apr 12, 2026
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A High-throughput Platform for the Screening of Salmonella spp./Shigella spp.
Published on: November 7, 2018
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Salmonella, Shigella, and yersinia
John P Dekker1, Karen M Frank1
1Department of Laboratory Medicine, Clinical Center, National Institutes of Health, 10 Center Drive, MSC 1508, Bethesda, MD 20892-1508, USA.
Clinics in Laboratory Medicine
|May 26, 2015
Summary
Salmonella, Shigella, and Yersinia cause significant foodborne illnesses. Newer diagnostic methods like mass spectrometry and polymerase chain reaction show promise for clinical testing.
Area of Science:
- Microbiology
- Infectious Diseases
- Clinical Diagnostics
Background:
- Salmonella, Shigella, and Yersinia are significant bacterial pathogens responsible for a wide range of human illnesses.
- These enteric pathogens cause millions of foodborne illnesses annually in the US, leading to substantial economic costs.
- Disease prevalence and case-fatality rates are higher in developing nations.
Purpose of the Study:
- To review the spectrum of diseases caused by Salmonella, Shigella, and Yersinia.
- To highlight the public health and economic impact of these infections.
- To discuss advancements in diagnostic methodologies.
Main Methods:
- Review of existing literature on Salmonella, Shigella, and Yersinia infections.
- Analysis of disease characteristics, clinical manifestations, and epidemiological data.
- Evaluation of traditional and emerging diagnostic techniques.
Main Results:
- These bacteria cause diseases ranging from asymptomatic carriage to severe conditions like hemorrhagic colitis and typhoidal fever.
- Foodborne illnesses linked to these pathogens incur significant healthcare and productivity costs.
- Emerging technologies such as mass spectrometry and polymerase chain reaction offer improved diagnostic potential.
Conclusions:
- Salmonella, Shigella, and Yersinia pose a considerable global health burden.
- Accurate and rapid diagnostics are crucial for effective disease management and control.
- Advanced molecular and spectrometric methods are poised to enhance routine clinical identification of these key enteric pathogens.
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