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Related Experiment Video

Updated: Apr 12, 2026

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
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Primary hepatic angiosarcoma.

P Chaudhary1, U Bhadana1, R A K Singh2

  • 1Lady Hardinge Medical College and Associated Dr Ram Manohar Lohia Hospital, New Delhi, India.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|May 27, 2015
PubMed
Summary
This summary is machine-generated.

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Primary hepatic angiosarcoma (HAS) is a rare, aggressive liver cancer. This review comprehensively covers its pathology, diagnosis, and current treatment limitations.

Area of Science:

  • Oncology
  • Hepatology
  • Pathology

Background:

  • Primary hepatic angiosarcoma (HAS) is a rare, aggressive liver malignancy.
  • It is the most common primary malignant mesenchymal tumor of the liver in adults, accounting for 2% of all primary hepatic malignancies.
  • While often associated with chemical carcinogens, 75% of HAS cases have unknown etiology.

Purpose of the Study:

  • To comprehensively review existing literature on primary hepatic angiosarcoma.
  • To provide detailed information and an update on this rare liver tumor.
  • To highlight diagnostic challenges and current therapeutic limitations.

Main Methods:

  • Systematic literature review of primary hepatic angiosarcoma.
  • Analysis of epidemiological data, clinical presentation, and pathological features.
Keywords:
Difficult and delayed diagnosisNo treatment guidelinesNon-specific symptomsPrimary hepatic angiosarcoma

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  • Evaluation of diagnostic markers (e.g., CD31) and imaging characteristics.
  • Review of current treatment strategies, including chemotherapy, resection, and transplant contraindications.

    • Main Results:

    • HAS is characterized by spindle or pleomorphic cells within hepatic vascular spaces.
    • Diagnosis often relies on pathological findings as imaging lacks specificity.
    • CD31 is identified as the most reliable diagnostic marker.
    • The tumor is typically multicentric, involving both liver lobes.

    Conclusions:

    • Established treatment guidelines are lacking due to the tumor's rarity and aggressiveness.
    • Chemotherapy offers palliative benefits.
    • Liver resection is considered for solitary masses; liver transplantation is contraindicated.
    • Further research is needed to improve understanding and treatment outcomes for HAS.