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Related Concept Videos

Hypoxia01:23

Hypoxia

2.6K
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
2.6K
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

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Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
787

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Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
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Hypoxic preconditioning: effect, mechanism and clinical implication (Part 1).

Guo-wei Lu, Guo Shao

    Zhongguo Ying Yong Sheng Li Xue Za Zhi = Zhongguo Yingyong Shenglixue Zazhi = Chinese Journal of Applied Physiology
    |May 29, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Hypoxic preconditioning (HPC) enhances tolerance to severe hypoxia by saving energy and improving brain plasticity. This adaptive mechanism, triggered by oxygen sensing, offers a novel strategy against hypoxia-ischemia and other stresses.

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    Area of Science:

    • Physiology
    • Molecular Biology
    • Evolutionary Biology

    Background:

    • Hypoxic preconditioning (HPC) confers resistance to subsequent severe hypoxia/ischemia.
    • HPC effects extend from local (LiHPC) to remote (ReHPC) and cross-pluripotential (CpHPC) forms, induced by various stresses.
    • Previous research has documented the effects of HPC.

    Purpose of the Study:

    • To systematically study the effects and mechanisms of HPC using a unique repetitive autohypoxia mouse model.
    • To investigate how HPC influences tolerance to hypoxia and protects against injury.
    • To explore the underlying mechanisms, including energy saving and brain plasticity.

    Main Methods:

    • Development of a unique animal model of repetitive autohypoxia in adult mice.
    • Systematic study of HPC effects on hypoxia tolerance and injury protection.
    • Analysis of changes in energy supply/demand, brain microorganization, learning/memory, neurochemicals, and antihypoxic genes/factors.

    Main Results:

    • Adult mice exposed to repetitive autohypoxia showed significantly increased tolerance to hypoxia and protection from injury.
    • Energy supply/demand decreased, brain microorganization and spatial learning/memory were maintained or improved.
    • Detrimental neurochemicals (free radicals) were down-regulated, while beneficial ones (adenosine, antihypoxic genes/factors) were up-regulated.

    Conclusions:

    • HPC's protective effects are fundamentally dependent on energy saving and brain plasticity, triggered by oxygen sensing and HIF-1 pathways.
    • HPC is an intrinsic evolutionary mechanism and a potential strategy against hypoxia-ischemia and other stresses.
    • HPC research supports developing antihypoxic gene/factor (AHF) medicines for therapeutic augmentation and critical care.