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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...

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Related Experiment Video

Updated: Apr 11, 2026

Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation

Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation

Published on: August 26, 2014

In Vivo Evaluation of 5-ASA Colon-Specific Tablets Using Experimental-Induced Colitis Rat Animal Model.

Sujata P Sawarkar¹, S G Deshpande², A N Bajaj³

¹SVKM's Dr. Bhanuben Nanavati College of Pharmacy, V.M Road, Vile Parle (W), Mumbai, 400 056, India. sujata.sawarkar@bncp.ac.in.

AAPS Pharmscitech

|May 29, 2015

Summary

This summary is machine-generated.

New colon-targeted 5-aminosalicylic acid (5-ASA) tablets using guar gum and pectin show improved efficacy for treating inflammatory bowel disease (IBD) in rat models compared to conventional oral delivery.

Keywords:

colitis colon-specific drug delivery myeloperoxidase

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Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

Area of Science:

Pharmacology
Drug Delivery Systems
Gastroenterology

Background:

Colonic drug delivery is crucial for treating inflammatory bowel disease (IBD) and systemic therapeutics.
Myeloperoxidase (MPO) levels indicate colon inflammation and drug efficacy for IBD.
Oral 5-aminosalicylic acid (5-ASA) is absorbed before reaching the colon, limiting its effectiveness.

Purpose of the Study:

To develop and evaluate colon-specific 5-aminosalicylic acid (5-ASA) tablets.
To assess the efficacy of these novel formulations in reducing colon inflammation.

Main Methods:

Formulation of 5-ASA tablets using natural polymers guar gum and pectin via compression coating.
In vitro evaluation using simulated gastrointestinal fluids.
In vivo assessment in a chemically induced colitis rat model (trinitrobenzenesulfonic acid and acetic acid).

Main Results:

Colon-specific 5-ASA tablets demonstrated effective drug release in the colon.
These formulations significantly reduced inflammation in the colitis rat model.
The novel 5-ASA tablets were more effective than oral sulfasalazine and conventional oral 5-ASA.

Conclusions:

Colon-targeted delivery of 5-ASA using guar gum and pectin is a viable strategy for IBD treatment.
This approach enhances therapeutic efficacy by ensuring drug availability in the colon.
Novel polymer-based formulations offer a promising alternative for managing inflammatory bowel diseases.