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Updated: Apr 11, 2026
05:40
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
Published on: July 29, 2021
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Emerging treatments for the primary headache disorders.
Nathaniel M Schuster1, Sarah Vollbracht, Alan M Rapoport
1Department of Neurology, Ronald Reagan-UCLA Medical Center, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Suite 1240, Los Angeles, CA, 90024, USA, nschuster@gmail.com.
Summary
Novel treatments for debilitating brain disorders like migraine and cluster headache are emerging. This review highlights new drugs, including anti-CGRP monoclonal antibodies, and neuromodulation devices, offering hope for better patient outcomes.
Area of Science:
- Neurology
- Pharmacology
- Biotechnology
Background:
- Migraine and cluster headache are prevalent, disabling neurological disorders.
- Current treatments have limitations, necessitating the development of novel therapeutic strategies.
Purpose of the Study:
- To review emerging pharmacologic and device-based treatments for migraine and cluster headache.
- To highlight recent advancements in anti-calcitonin gene-related peptide (CGRP) therapies and neuromodulation techniques.
Main Methods:
- Review of recent clinical trial data for novel migraine and cluster headache treatments.
- Focus on monoclonal antibodies targeting CGRP and its receptor.
- Evaluation of neuromodulation devices and alternative drug delivery systems.
Main Results:
- Phase 2 trials show promise for anti-CGRP monoclonal antibodies (LY2951742, ALD403, TEV-48125).
- Positive results from randomized controlled trials of sphenopalatine ganglion stimulation, trigeminal nerve stimulation, transcutaneous vagus nerve stimulation, and transcranial magnetic stimulation.
- Exploration of novel delivery methods for existing medications like triptans and dihydroergotamine.
Conclusions:
- Emerging therapies, including anti-CGRP mAbs and neuromodulation, demonstrate significant potential for managing migraine and cluster headache.
- Advancements in drug delivery offer improved patient convenience and efficacy.
- These novel treatments represent a promising frontier in headache disorder management.
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