Related Experiment Video
Updated: Apr 11, 2026

Direct Intrathecal Injection of Recombinant Adeno-associated Viruses in Adult Mice
Published on: February 15, 2019
[Adjuvants in modern anesthesia - lidocaine]
Local anesthetics (LA) possess anti-inflammatory properties beyond pain relief. These effects, particularly with intravenous lidocaine, may improve recovery after abdominal surgery.
Area of Science:
- Pharmacology of local anesthetics
- Immunomodulatory effects of drugs
- Perioperative medicine
Context:
- Local anesthetics (LA) are recognized for pain and arrhythmia management.
- Emerging evidence suggests LA exhibit anti-inflammatory and immunomodulatory activities.
- Intravenous lidocaine is used perioperatively in abdominal surgery.
Purpose:
- To explore the anti-inflammatory and immunomodulatory effects of local anesthetics.
- To understand how these alternative properties contribute to clinical benefits.
- To investigate the impact of systemic LA on postoperative recovery.
Summary:
- Local anesthetics demonstrate anti-inflammatory properties in addition to their known antinociceptive and antiarrhythmic effects.
- These immunomodulatory actions of systemic LA, such as lidocaine, may explain observed clinical benefits.
- Perioperative intravenous lidocaine has been shown to reduce postoperative pain, improve bowel function, and shorten hospital stays.
Impact:
- Highlights the multifaceted therapeutic potential of local anesthetics.
- Suggests novel applications for LA in managing inflammation and enhancing surgical recovery.
- Provides a basis for further research into the immunomodulatory mechanisms of LA.
More Related Videos
05:43Topical Airway Anesthesia for Awake-endoscopic Intubation Using the Spray-as-you-go Technique with High Oxygen Flow
Published on: January 13, 2017
05:39Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
Published on: May 26, 2023
Related Concept Videos
Local Anesthetics: Common Agents and Their Applications
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia
Local Anesthetics: Chemistry and Structure-Activity Relationship
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...
Local Anesthetics: Clinical Application as Spinal Anesthesia