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Oral immunotherapy and potential treatment
Sakura Sato1, Noriyuki Yanagida, Motohiro Ebisawa
1Department of Allergy, Clinical Research Center for Allergology and Rheumatology, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan.
Chemical Immunology and Allergy
|May 30, 2015
Summary
Oral immunotherapy (OIT) shows promise for food allergy desensitization but may cause side effects. Novel approaches like sublingual immunotherapy and omalizumab offer alternatives with fewer adverse reactions and improved food tolerance.
Area of Science:
- Immunology
- Allergy Research
- Gastroenterology
Background:
- Current food allergy treatment relies on allergen avoidance.
- Oral immunotherapy (OIT) induces desensitization but can cause mild to moderate symptoms and long-term tolerance is not guaranteed.
Purpose of the Study:
- To review novel therapeutic approaches for food allergy.
- To compare the efficacy and safety of OIT with newer treatments.
Main Methods:
- Review of studies on sublingual immunotherapy, epicutaneous immunotherapy, and omalizumab.
- Examination of combination therapies, including OIT with omalizumab.
Main Results:
- Novel therapies like sublingual and epicutaneous immunotherapy show promise with fewer adverse reactions than OIT.
- Omalizumab, alone or combined with OIT, may increase food tolerance and threshold doses.
Conclusions:
- Newer food allergy treatments, including omalizumab and OIT combinations, offer potential benefits.
- Further research is needed to confirm the long-term safety and efficacy of these novel approaches.
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